Important Facts About DOVATOThis is only a brief summary of important information about DOVATO anddoes not replace talking to your healthcare provider about your condition andtreatment.What is the Most Important Information I Should Know about DOVATO?If you have both human immunodeficiency virus-1 (HIV-1) and hepatitis B virus(HBV) infection, DOVATO can cause serious side effects, including: Resistant HBV infection. Your healthcare provider will test you for HBV infection before prescription and over-the-counter medicines, vitamins, and herbal supplements.you start treatment with DOVATO. If you have HIV-1 and hepatitis B, the hepatitis B virus can Some medicines interact with DOVATO. Keep a list of your medicines and show it to yourchange (mutate) during your treatment with DOVATO and become harder to treat (resistant). healthcare provider and pharmacist when you get a new medicine.It is not known if DOVATO is safe and effective in people who have HIV-1 and HBV infection. Worsening of HBV infection. If you have HIV-1 and HBV infection, your HBV mayget worse (tlare-up) it you stop taking DOVATO. A "lare-up" is when your HBV infectionsuddenly returns in a worse way than before. Worsening liver disease can be serious andmay lead to death. Do not run out of DOVATO. Refil your prescription or talk to your healthcare providerbefore your DOVATO is all gone. Do not stop DOVATO without first talking to your healthcare provider. If youstop taking DOVATO, your healthcare provider will need to check your health often and doblood tests regularly for several months to check your liver.What is DOVATO?Tell your healthcare provider about all of your medical conditions, includingit you: (cont'd) are breastfeeding or plan to breastfeed. Do not breastfeed if you take DOVATO. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby. One of the medicines in DOVATO (lamivudine) passes into your breastmilk. Talk with your healthcare provider about the best way to feed your baby.Tell your healthcare provider about all the medicines you take, including You can ask your healthcare provider or pharmacist for a list of medicines that interactwith DOVATO. Do not start taking a new medicine without telling your healthcare provider.Your healthcare provider can tell you if it is safe to take DOVATO with other medicines.What are Possible Side Effects of DOVATO?DOVATO can cause serious side effects, including: Those in the "What is the Most Important Information I Should Know aboutDOVATO?" section. Allergic reactions. Call your healthcare provider right away if you develop arash with DOVATO. Stop taking DOVATO and get medical help right away ifyou develop a rash with any of the following signs or symptoms: fever; generallyill feeling: tiredness; muscle or joint aches; blisters or sores in mouth; blisters or peelingof the skin; redness or swelling of the eyes, swelling of the mouth, face, lips, or tongue;problems breathing. Liver problems. People with a history of hepatitis B or C virus may have an increasedrisk of developing new or worsening changes in certain liver tests during treatment withDOVATO. Liver problems, including liver failure, have also happened in people without ahistory of liver disease or other risk factors. Your healthcare provider may do blood teststo check your liver.Tell your healthcare provider right away if you get any of the following signsor symptoms of liver problems: your skin or the white part of your eyes turns yellow(jaundice): dark or "tea-colored" urine, light-colored stools (bowel movements); nauseaor vomiting; loss of appetite, and/or pain, aching, or tenderness on the right side of yourstomach area. Too much lactic acid in your blood (lactic acidosis). Lactic acidosis is a seriousmedical emergency that can lead to death. Tell your healthcare provider right awayif you get any of the following symptoms that could be signs of lactic acidosis:feel very weak or tired; unusual (not normal) muscle pain; trouble breathing: stomachpain with nausea and vomiting; feel cold, especially in your arms and legs, feel dizzy orlightheaded; and/or a fast or irregular heartbeat. Lactic acidosis can also lead to severe liver problems, which can lead todeath. Your liver may become large (hepatomegaly) and you may develop fat in your liver(steatosis). Tell your healthcare provider right away if you get any of the signs orsymptoms of liver problems which are listed above under "Liver problems."You may be more likely to get lactic acidosis or severe liver problems if youare female or very overweight (obese).DOVATO is a prescription medicine that is used without other antiretroviral medicines to treatHIV-1 infection in adults who have not received antiretroviral medicines in the past, andwithout known resistance to the medicines dolutegravir or lamivudine. HIV-1 is the virus thatcauses Acquired Immune Deficiency Syndrome (AIDS). It is not known if DOVATO is safe andeffective in children.Who should not take DOVATO?Do Not Take DOVATO if You: have ever had an allergic reaction to a medicine that contains dolutegravir or lamivudine. take dofetilide.What should I tell my healthcare provider before using DOVATO?Tell your healthcare provider about all of your medical conditions, includingif you: have or have had liver problems, including hepatitis B or C infection. have kidney problems. are pregnant or plan to become pregnant. One of the medicines in DOVATO (dolutegravir)may harm your unborn baby. Your healthcare provider may prescribe a different medicine than DOVATO if you areplanning to become pregnant or if pregnancy is confirmed in the first 12 weeks ofpregnancy. it you can become pregnant, your healthcare provider will perform a pregnancy test beforeyou start treatment with DOVATO. Íf you can become pregnant, you should consistently use effective birth control(contraception) during treatment with DOVATÓ. Tell your healthcare provider right away if you are planning to become pregnant, youbecome pregnant, or think you may be pregnant during treatment with DOVATO.ViiVConnectFor information on access and coverage to helpe2020 VIIV Healthcare or licensor.ViiV DLLADVT190033 January 2020Healtheare Produced in USA.you get your prescribed VIV Healthcare medicationsInsured · Underinsured  Uninsured1-844-588-3288 (toll free)www.vilvconnect.comLearn moreMonday-Friday, 8AM-11rm ()about Alphonsoand DOVATO atDOVATO.com Important Facts About DOVATO This is only a brief summary of important information about DOVATO and does not replace talking to your healthcare provider about your condition and treatment. What is the Most Important Information I Should Know about DOVATO? If you have both human immunodeficiency virus-1 (HIV-1) and hepatitis B virus (HBV) infection, DOVATO can cause serious side effects, including:  Resistant HBV infection. Your healthcare provider will test you for HBV infection before prescription and over-the-counter medicines, vitamins, and herbal supplements. you start treatment with DOVATO. If you have HIV-1 and hepatitis B, the hepatitis B virus can Some medicines interact with DOVATO. Keep a list of your medicines and show it to your change (mutate) during your treatment with DOVATO and become harder to treat (resistant). healthcare provider and pharmacist when you get a new medicine. It is not known if DOVATO is safe and effective in people who have HIV-1 and HBV infection.  Worsening of HBV infection. If you have HIV-1 and HBV infection, your HBV may get worse (tlare-up) it you stop taking DOVATO. A "lare-up" is when your HBV infection suddenly returns in a worse way than before. Worsening liver disease can be serious and may lead to death.  Do not run out of DOVATO. Refil your prescription or talk to your healthcare provider before your DOVATO is all gone.  Do not stop DOVATO without first talking to your healthcare provider. If you stop taking DOVATO, your healthcare provider will need to check your health often and do blood tests regularly for several months to check your liver. What is DOVATO? Tell your healthcare provider about all of your medical conditions, including it you: (cont'd)  are breastfeeding or plan to breastfeed. Do not breastfeed if you take DOVATO.  You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby.  One of the medicines in DOVATO (lamivudine) passes into your breastmilk.  Talk with your healthcare provider about the best way to feed your baby. Tell your healthcare provider about all the medicines you take, including  You can ask your healthcare provider or pharmacist for a list of medicines that interact with DOVATO.  Do not start taking a new medicine without telling your healthcare provider. Your healthcare provider can tell you if it is safe to take DOVATO with other medicines. What are Possible Side Effects of DOVATO? DOVATO can cause serious side effects, including:  Those in the "What is the Most Important Information I Should Know about DOVATO?" section.  Allergic reactions. Call your healthcare provider right away if you develop a rash with DOVATO. Stop taking DOVATO and get medical help right away if you develop a rash with any of the following signs or symptoms: fever; generally ill feeling: tiredness; muscle or joint aches; blisters or sores in mouth; blisters or peeling of the skin; redness or swelling of the eyes, swelling of the mouth, face, lips, or tongue; problems breathing.  Liver problems. People with a history of hepatitis B or C virus may have an increased risk of developing new or worsening changes in certain liver tests during treatment with DOVATO. Liver problems, including liver failure, have also happened in people without a history of liver disease or other risk factors. Your healthcare provider may do blood tests to check your liver. Tell your healthcare provider right away if you get any of the following signs or symptoms of liver problems: your skin or the white part of your eyes turns yellow (jaundice): dark or "tea-colored" urine, light-colored stools (bowel movements); nausea or vomiting; loss of appetite, and/or pain, aching, or tenderness on the right side of your stomach area.  Too much lactic acid in your blood (lactic acidosis). Lactic acidosis is a serious medical emergency that can lead to death. Tell your healthcare provider right away if you get any of the following symptoms that could be signs of lactic acidosis: feel very weak or tired; unusual (not normal) muscle pain; trouble breathing: stomach pain with nausea and vomiting; feel cold, especially in your arms and legs, feel dizzy or lightheaded; and/or a fast or irregular heartbeat.  Lactic acidosis can also lead to severe liver problems, which can lead to death. Your liver may become large (hepatomegaly) and you may develop fat in your liver (steatosis). Tell your healthcare provider right away if you get any of the signs or symptoms of liver problems which are listed above under "Liver problems." You may be more likely to get lactic acidosis or severe liver problems if you are female or very overweight (obese). DOVATO is a prescription medicine that is used without other antiretroviral medicines to treat HIV-1 infection in adults who have not received antiretroviral medicines in the past, and without known resistance to the medicines dolutegravir or lamivudine. HIV-1 is the virus that causes Acquired Immune Deficiency Syndrome (AIDS). It is not known if DOVATO is safe and effective in children. Who should not take DOVATO? Do Not Take DOVATO if You:  have ever had an allergic reaction to a medicine that contains dolutegravir or lamivudine.  take dofetilide. What should I tell my healthcare provider before using DOVATO? Tell your healthcare provider about all of your medical conditions, including if you:  have or have had liver problems, including hepatitis B or C infection.  have kidney problems.  are pregnant or plan to become pregnant. One of the medicines in DOVATO (dolutegravir) may harm your unborn baby.  Your healthcare provider may prescribe a different medicine than DOVATO if you are planning to become pregnant or if pregnancy is confirmed in the first 12 weeks of pregnancy.  it you can become pregnant, your healthcare provider will perform a pregnancy test before you start treatment with DOVATO.  Íf you can become pregnant, you should consistently use effective birth control (contraception) during treatment with DOVATÓ.  Tell your healthcare provider right away if you are planning to become pregnant, you become pregnant, or think you may be pregnant during treatment with DOVATO. ViiVConnect For information on access and coverage to help e2020 VIIV Healthcare or licensor. ViiV DLLADVT190033 January 2020 Healtheare Produced in USA. you get your prescribed VIV Healthcare medications Insured · Underinsured  Uninsured 1-844-588-3288 (toll free) www.vilvconnect.com Learn more Monday-Friday, 8AM-11rm () about Alphonso and DOVATO at DOVATO.com

Date: May 13, 2020

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Important Facts About DOVATO This is only a brief summary of important information about DOVATO and does not replace talking to your healthcare provider about your condition and treatment. What is the Most Important Information I Should Know about DOVATO? If you have both human immunodeficiency virus-1 (HIV-1) and hepatitis B virus (HBV) infection, DOVATO can cause serious side effects, including: Resistant HBV infection. Your healthcare provider will test you for HBV infection before prescription and over-the-counter medicines, vitamins, and herbal supplements. you start treatment with DOVATO. If you have HIV-1 and hepatitis B, the hepatitis B virus can Some medicines interact with DOVATO. Keep a list of your medicines and show it to your change (mutate) during your treatment with DOVATO and become harder to treat (resistant). healthcare provider and pharmacist when you get a new medicine. It is not known if DOVATO is safe and effective in people who have HIV-1 and HBV infection. Worsening of HBV infection. If you have HIV-1 and HBV infection, your HBV may get worse (tlare-up) it you stop taking DOVATO. A "lare-up" is when your HBV infection suddenly returns in a worse way than before. Worsening liver disease can be serious and may lead to death. Do not run out of DOVATO. Refil your prescription or talk to your healthcare provider before your DOVATO is all gone. Do not stop DOVATO without first talking to your healthcare provider. If you stop taking DOVATO, your healthcare provider will need to check your health often and do blood tests regularly for several months to check your liver. What is DOVATO? Tell your healthcare provider about all of your medical conditions, including it you: (cont'd) are breastfeeding or plan to breastfeed. Do not breastfeed if you take DOVATO. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby. One of the medicines in DOVATO (lamivudine) passes into your breastmilk. Talk with your healthcare provider about the best way to feed your baby. Tell your healthcare provider about all the medicines you take, including You can ask your healthcare provider or pharmacist for a list of medicines that interact with DOVATO. Do not start taking a new medicine without telling your healthcare provider. Your healthcare provider can tell you if it is safe to take DOVATO with other medicines. What are Possible Side Effects of DOVATO? DOVATO can cause serious side effects, including: Those in the "What is the Most Important Information I Should Know about DOVATO?" section. Allergic reactions. Call your healthcare provider right away if you develop a rash with DOVATO. Stop taking DOVATO and get medical help right away if you develop a rash with any of the following signs or symptoms: fever; generally ill feeling: tiredness; muscle or joint aches; blisters or sores in mouth; blisters or peeling of the skin; redness or swelling of the eyes, swelling of the mouth, face, lips, or tongue; problems breathing. Liver problems. People with a history of hepatitis B or C virus may have an increased risk of developing new or worsening changes in certain liver tests during treatment with DOVATO. Liver problems, including liver failure, have also happened in people without a history of liver disease or other risk factors. Your healthcare provider may do blood tests to check your liver. Tell your healthcare provider right away if you get any of the following signs or symptoms of liver problems: your skin or the white part of your eyes turns yellow (jaundice): dark or "tea-colored" urine, light-colored stools (bowel movements); nausea or vomiting; loss of appetite, and/or pain, aching, or tenderness on the right side of your stomach area. Too much lactic acid in your blood (lactic acidosis). Lactic acidosis is a serious medical emergency that can lead to death. Tell your healthcare provider right away if you get any of the following symptoms that could be signs of lactic acidosis: feel very weak or tired; unusual (not normal) muscle pain; trouble breathing: stomach pain with nausea and vomiting; feel cold, especially in your arms and legs, feel dizzy or lightheaded; and/or a fast or irregular heartbeat. Lactic acidosis can also lead to severe liver problems, which can lead to death. Your liver may become large (hepatomegaly) and you may develop fat in your liver (steatosis). Tell your healthcare provider right away if you get any of the signs or symptoms of liver problems which are listed above under "Liver problems." You may be more likely to get lactic acidosis or severe liver problems if you are female or very overweight (obese). DOVATO is a prescription medicine that is used without other antiretroviral medicines to treat HIV-1 infection in adults who have not received antiretroviral medicines in the past, and without known resistance to the medicines dolutegravir or lamivudine. HIV-1 is the virus that causes Acquired Immune Deficiency Syndrome (AIDS). It is not known if DOVATO is safe and effective in children. Who should not take DOVATO? Do Not Take DOVATO if You: have ever had an allergic reaction to a medicine that contains dolutegravir or lamivudine. take dofetilide. What should I tell my healthcare provider before using DOVATO? Tell your healthcare provider about all of your medical conditions, including if you: have or have had liver problems, including hepatitis B or C infection. have kidney problems. are pregnant or plan to become pregnant. One of the medicines in DOVATO (dolutegravir) may harm your unborn baby. Your healthcare provider may prescribe a different medicine than DOVATO if you are planning to become pregnant or if pregnancy is confirmed in the first 12 weeks of pregnancy. it you can become pregnant, your healthcare provider will perform a pregnancy test before you start treatment with DOVATO. Íf you can become pregnant, you should consistently use effective birth control (contraception) during treatment with DOVATÓ. Tell your healthcare provider right away if you are planning to become pregnant, you become pregnant, or think you may be pregnant during treatment with DOVATO. ViiVConnect For information on access and coverage to help e2020 VIIV Healthcare or licensor. ViiV DLLADVT190033 January 2020 Healtheare Produced in USA. you get your prescribed VIV Healthcare medications Insured · Underinsured Uninsured 1-844-588-3288 (toll free) www.vilvconnect.com Learn more Monday-Friday, 8AM-11rm () about Alphonso and DOVATO at DOVATO.com Important Facts About DOVATO This is only a brief summary of important information about DOVATO and does not replace talking to your healthcare provider about your condition and treatment. What is the Most Important Information I Should Know about DOVATO? If you have both human immunodeficiency virus-1 (HIV-1) and hepatitis B virus (HBV) infection, DOVATO can cause serious side effects, including: Resistant HBV infection. Your healthcare provider will test you for HBV infection before prescription and over-the-counter medicines, vitamins, and herbal supplements. you start treatment with DOVATO. If you have HIV-1 and hepatitis B, the hepatitis B virus can Some medicines interact with DOVATO. Keep a list of your medicines and show it to your change (mutate) during your treatment with DOVATO and become harder to treat (resistant). healthcare provider and pharmacist when you get a new medicine. It is not known if DOVATO is safe and effective in people who have HIV-1 and HBV infection. Worsening of HBV infection. If you have HIV-1 and HBV infection, your HBV may get worse (tlare-up) it you stop taking DOVATO. A "lare-up" is when your HBV infection suddenly returns in a worse way than before. Worsening liver disease can be serious and may lead to death. Do not run out of DOVATO. Refil your prescription or talk to your healthcare provider before your DOVATO is all gone. Do not stop DOVATO without first talking to your healthcare provider. If you stop taking DOVATO, your healthcare provider will need to check your health often and do blood tests regularly for several months to check your liver. What is DOVATO? Tell your healthcare provider about all of your medical conditions, including it you: (cont'd) are breastfeeding or plan to breastfeed. Do not breastfeed if you take DOVATO. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby. One of the medicines in DOVATO (lamivudine) passes into your breastmilk. Talk with your healthcare provider about the best way to feed your baby. Tell your healthcare provider about all the medicines you take, including You can ask your healthcare provider or pharmacist for a list of medicines that interact with DOVATO. Do not start taking a new medicine without telling your healthcare provider. Your healthcare provider can tell you if it is safe to take DOVATO with other medicines. What are Possible Side Effects of DOVATO? DOVATO can cause serious side effects, including: Those in the "What is the Most Important Information I Should Know about DOVATO?" section. Allergic reactions. Call your healthcare provider right away if you develop a rash with DOVATO. Stop taking DOVATO and get medical help right away if you develop a rash with any of the following signs or symptoms: fever; generally ill feeling: tiredness; muscle or joint aches; blisters or sores in mouth; blisters or peeling of the skin; redness or swelling of the eyes, swelling of the mouth, face, lips, or tongue; problems breathing. Liver problems. People with a history of hepatitis B or C virus may have an increased risk of developing new or worsening changes in certain liver tests during treatment with DOVATO. Liver problems, including liver failure, have also happened in people without a history of liver disease or other risk factors. Your healthcare provider may do blood tests to check your liver. Tell your healthcare provider right away if you get any of the following signs or symptoms of liver problems: your skin or the white part of your eyes turns yellow (jaundice): dark or "tea-colored" urine, light-colored stools (bowel movements); nausea or vomiting; loss of appetite, and/or pain, aching, or tenderness on the right side of your stomach area. Too much lactic acid in your blood (lactic acidosis). Lactic acidosis is a serious medical emergency that can lead to death. Tell your healthcare provider right away if you get any of the following symptoms that could be signs of lactic acidosis: feel very weak or tired; unusual (not normal) muscle pain; trouble breathing: stomach pain with nausea and vomiting; feel cold, especially in your arms and legs, feel dizzy or lightheaded; and/or a fast or irregular heartbeat. Lactic acidosis can also lead to severe liver problems, which can lead to death. Your liver may become large (hepatomegaly) and you may develop fat in your liver (steatosis). Tell your healthcare provider right away if you get any of the signs or symptoms of liver problems which are listed above under "Liver problems." You may be more likely to get lactic acidosis or severe liver problems if you are female or very overweight (obese). DOVATO is a prescription medicine that is used without other antiretroviral medicines to treat HIV-1 infection in adults who have not received antiretroviral medicines in the past, and without known resistance to the medicines dolutegravir or lamivudine. HIV-1 is the virus that causes Acquired Immune Deficiency Syndrome (AIDS). It is not known if DOVATO is safe and effective in children. Who should not take DOVATO? Do Not Take DOVATO if You: have ever had an allergic reaction to a medicine that contains dolutegravir or lamivudine. take dofetilide. What should I tell my healthcare provider before using DOVATO? Tell your healthcare provider about all of your medical conditions, including if you: have or have had liver problems, including hepatitis B or C infection. have kidney problems. are pregnant or plan to become pregnant. One of the medicines in DOVATO (dolutegravir) may harm your unborn baby. Your healthcare provider may prescribe a different medicine than DOVATO if you are planning to become pregnant or if pregnancy is confirmed in the first 12 weeks of pregnancy. it you can become pregnant, your healthcare provider will perform a pregnancy test before you start treatment with DOVATO. Íf you can become pregnant, you should consistently use effective birth control (contraception) during treatment with DOVATÓ. Tell your healthcare provider right away if you are planning to become pregnant, you become pregnant, or think you may be pregnant during treatment with DOVATO. ViiVConnect For information on access and coverage to help e2020 VIIV Healthcare or licensor. ViiV DLLADVT190033 January 2020 Healtheare Produced in USA. you get your prescribed VIV Healthcare medications Insured · Underinsured Uninsured 1-844-588-3288 (toll free) www.vilvconnect.com Learn more Monday-Friday, 8AM-11rm () about Alphonso and DOVATO at DOVATO.com

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